Venus 6 includes a REST API for method control. It is not turned on by default, there’s instructions for starting the service here. I think like @Huajiang said you can still use the old ActiveX control.
The new API allows you to inject a variable value into a method. You have to load the method, inject the variable value(s), then start the method. I’m pretty sure the old API does not have the ability to set variable values.