Tip type and Liquid Class

Tips are probably a smaller contributing factor than the type of liquid and/or liquid class in use. Is this a soapy or viscous solution? Things like dispense speed, blowout, etc are all going to have much bigger impact than the tip type.

For a quick test you can likely just pick up a benchtop pipette and try to figure out some cases that lead to bubble formation.

Lots of great resources on this site to help with LC creation, and feel free to add some info about your specific liquid type and folks will definitely chime in with suggestions

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