Have any folks gone through with the CO-RE II hardware upgrade yet? Seen any noticeable improvements or differences in results? Would like to hear what you like and what you don’t like thus far.
Is there a new service software interface?
I also heard that Hamilton may be extending out the June 2024 deadline since lots of customers complained about building up a large CO-RE tip stock after the terrible supply chain issues of the pandemic. Can any Hamilton employees shed any light on a potential deadline extension? Thank you all in advance.
There is no new service software interface for CO-RE II, but there is specific firmware that must be uploaded. The June 2024 deadline is for free upgrades. If that deadline changes, I will update this thread!
In terms of feedback, the applications team has reported that tip straightness is noticeably improved. We haven’t seen differences in assay results - we understand that this would be of primary concern to our customers. While we’ve encountered some reports, further investigation has shown that the issues were not due to the switch to CO-RE II.
See this link to the original announcement that includes a link to the brochure with more information.
All of the features of CO-RE II are desirable and look like great improvements. Just curious as to the reception in the field thus far. Others, please share your experiences if you wish.
So far so good. We have done a number of CORE II upgrades. We compared with Artel, the CORE I and CORE II tips, and then with the CORE II hardware upgrade, its passed Artel fine also with no changes to method.
@EricSindelar_Hamilton Just wanted to follow up to see if there is any change to the June 2024 deadline for free upgrades to CO-RE II. Can you also elaborate if its good until the start of June or the end of June? Thanks!
Bump. Looking into the same type of thing in my lab. We have the option of a system with CO-RE I or CO-RE II and curious about some experiences from the field. Seems like there may be some special Tip adapters required? And maybe some issues with 50µL tip pickup but apparently no issue in terms of volume delivery?
@StevenO No issues with our labs with CO-RE II, I used to have data from Hamilton showcasing the specifications of CO-RE I vs. CO-RE II but don’t any longer. You can definitely ask them for it.
@evwolfson I would get the upgraded system unless you’re willing to shell out money for an upgrade eventually or manage with third party tips in the future. No issues with the 50s from us, we use Hamilton tips as well.
The stop disks are longer on CORE II. When doing shifted tip pickup on MPH CORE II on tip adapter/support it will collide with other tip frames. The CORE II tip adapter is higher than CORE I tip adapter and avoids the collisions.
Below is an image of the tip support. So, you’d need the version compatible with CO-RE II. They’ll look similar but the new part has a label indicating it’s CO-RE II.
