Anyone out there using fixed tip / liquid filled systems to dispense DMSO for compound solubilization? I’ve seen this on some old Tecan EVOs - are there any other options?
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I’d recommend avoiding that setup if possible.I serviced one such system a long time ago, but I still remember it today because it was a nightmare 
it worked, but it was very rough on the system, and very difficult to complete OQ reliably.
If I remember correctly there’s options to have a setup where there’s basically multiple liquid systems sharing the tips, maybe that’s a bit better but they aren’t widely used as far as I recall.
We had 20-30 Tecan systems with DMSO as the system liquid with almost no problems (related to DMSO as the system liquid). They sell tubing rated for DMSO so make sure you get that otherwise it solubilizes the standard lines and causes all sorts of problems.
It gets kind of expensive to do flushes and you have to manage waste a bit more, but we were buying DMSO in Nowpak containers, I believe they were 20L containers. We’d plug those right into the system liquid. The HTS sites considered plumbing DMSO to the Tecans in the same way that some buildings may have RODI water plumbed. I don’t believe they ever did it.
At one point we had a need to use deuterated DMSO for a bunch of samples. We actually switched an entire system to deuterated DMSO system liquid. At $1000/L that got expensive really quickly. But they chemistry teams paid for it, so what did I care? 
Still remember the difference in smell of dDMSO…
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this application is best handled using liquid filled technology, which is Tecan’s wheelhouse - Fluent can handle this,
Chemically resistant tubing etc, DMSO system fluid container
other fluid filled system could be Perkin Elmer or Beckman - but they don’t have the flexibility in fixed tips for vial access etc
Been doing this kinda work for 25+ years - remember 5-6 x Tecan Genesis back in 2000 running this for huge compound management facility - same can run on Fluent (only difference is software takes 3-4 minutes to open and start up with FluentControl; Gemini took about 8 seconds on a bad day!)
Thanks for the perspectives everyone.
1+ to this - crazy. And think how much faster the PCs are too.